Pharmacogenomics and mechanistic basis of drug hypersensitivity

药物超敏反应的药物基因组学和机制基础

• 批准号: nhmrc : 1064524
• 负责人: A/Pr Lloyd D'Orsogna
• 金额: $ 45.16万
• 依托单位: Murdoch University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/pharmacogenomics-mechanistic-basis-drug-hypersensitivity/455123
• 关键词: Pharmacogenomics; mechanistic; basis; drug; hypersensitivity

Drug allergy causes physical harm, anxiety and may limit treatment options. We introduced personalised genetic testing to prevent one such drug hypersensitivity. Genetic information from patients who have had adverse drug reactions will be used to work out how drugs trigger severe allergic reactions and develop strategies to predict these reactions and design safer drugs. This research has relevance to our understanding of other inflammatory disease such as autoimmune disease and multiple sclerosis.

药物过敏会导致身体伤害，焦虑，并可能限制治疗选择。我们引入了个性化的基因检测，以防止这种药物过敏。来自有药物不良反应的患者的遗传信息将用于研究药物如何引发严重的过敏反应，并制定预测这些反应和设计更安全药物的策略。这项研究与我们对其他炎症性疾病如自身免疫性疾病和多发性硬化症的理解有关。