Plasmodium knowlesi as a genetic model for Plasmodium vivax drug resistance

世界上大多数疟疾是由两种不同的疟原虫引起的。然而，间日疟原虫是一种无法在实验室培养的病毒，因此研究很少。已经观察到耐药性，但对其根本原因了解甚少。我们建议使用一种密切相关的寄生虫，诺氏疟原虫作为模型来了解耐药机制。这些知识将用于实地跟踪耐药性并指导最适当的治疗政策。

Two different Plasmodium parasites cause the majority of malaria worldwide. However, one type, P. vivax, is unable to be cultured in the laboratory and therefore has been poorly studied. Drug resistance has been observed but the underlying causes are poorly understood. We propose to use a closely related parasite, P. knowlesi, as a model to understand drug resistance mechanisms. This knowledge will be used to follow resistance in the field and direct policy of the most appropriate treatment.