Plasmodium knowlesi as a genetic model for Plasmodium vivax drug resistance

诺氏疟原虫作为间日疟原虫耐药性的遗传模型

• 批准号: nhmrc : GNT1148392
• 负责人: Dr Brendan Elsworth
• 金额: $ 40.88万
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/plasmodium-knowlesi-genetic-drug-resistance/1348876
• 关键词: Plasmodium; knowlesi; genetic; model; vivax

Two different Plasmodium parasites cause the majority of malaria worldwide. However, one type, P. vivax, is unable to be cultured in the laboratory and therefore has been poorly studied. Drug resistance has been observed but the underlying causes are poorly understood. We propose to use a closely related parasite, P. knowlesi, as a model to understand drug resistance mechanisms. This knowledge will be used to follow resistance in the field and direct policy of the most appropriate treatment.

两种不同的疟原虫寄生虫引起了世界上大多数疟疾。然而，有一种类型，间日疟原虫，无法在实验室中培养，因此研究得很少。已经观察到耐药性，但对根本原因知之甚少。我们建议使用密切相关的寄生虫诺氏疟原虫作为模型来了解耐药机制。这些知识将用于跟踪田间的耐药性，并指导最适当治疗的政策。