Polyunsaturated fat as a protective agent in the dietary management of early overweight

这项研究大大增加了我们对饮食组成对体重管理的影响的认识。它建立在动物模型研究的基础上，证明了不同类型的脂肪对肥胖发展的影响，以及我们对糖尿病患者的研究，我们发现低脂肪饮食中多不饱和脂肪的比例较高，会导致更多的体脂减少。我们提出的研究将证明同样的饮食结构是否可以减少超重但非糖尿病人的内脏脂肪，以及我们是否需要减少卡路里来达到这一目的。这种影响可能是由于用作燃料的脂肪含量较高、代谢率较高或食欲下降所致。我们将能够确定这些影响，并增加饮食成分和能量平衡的科学知识基础。如果我们要为体重管理制定比一般的饮食建议更具体、更有效的饮食建议，那么了解这些知识是很重要的。本研究的一大优势在于食品指导系统的完善。我们不仅将证明饮食的目标营养成分是实现的，食物指导系统为人们在自由的生活条件下选择食物提供了帮助。因此，该研究与临床实践模型的联系将得到保证。这项研究的影响可能会在更有效的临床策略方面进行评估，以管理肥胖，这是一个主要的公共卫生问题。

This study adds significantly to our knowledge of the effect of diet composition on weight management. It builds on animal model studies demonstrating the effects of different types of fat on obesity development, and on our research in people with diabetes, where we found a higher proportion of polyunsaturated fats in a low fat diet resulted in greater body fat loss. Our proposed research will demonstrate whether this same dietary profile can reduce visceral fat in people who are overweight but not diabetic, and whether we need to reduce calories or not to achieve this end. It may be that the effect is due to a higher level of fat used as fuel, a higher metabolic rate, or a reduction in appetite. We will be able to determine these effects, and add to the scientific knowledge base of dietary components and energy balance. Having this knowledge is important if we are to develop dietary advice for weight management that is more specific and effective than general statements on eating well. One of the great strengths of this study is that the food guidance system is fully developed. Not only will we will prove the targeted nutrient composition of the diet is achieved, the food guidance system provides for people to chose foods under free living conditions. Thus the link to this research and clinical practice models will be assured. The impact of this research may then be assessed in terms of more effective clinical strategies for the management of obesity, a major public health concern.