Predicting, diagnosing and treating synucleinopathies

帕金森病和路易体痴呆具有很高的社会经济负担，目前没有改善疾病的治疗方法。现有的对症治疗侧重于替换由在临床诊断之前大部分已经退化的神经元产生的神经递质，这显然需要在患者可能从神经保护干预中获益最多的阶段识别病例，以及改善症状和发展疾病修饰治疗。

Parkinson’s Disease and Lewy Body Dementia carry a high socioeconomic burden and there are currently no disease-modifying treatments. Existing symptomatic therapies focus on replacing neurotransmitters that are made by neurons that have mostly degenerated prior to clinical diagnosis, warranting a clear need to identify cases at a stage when they might benefit most from neuroprotective interventions, as well as improving symptomatic and developing disease modifying treatments.