MOLECULAR APPROACHES TO OVERCOME SCABIES AND ASSOCIATED DISEASE

克服疥疮及相关疾病的分子方法

• 批准号: FT130101875
• 负责人: Dr Katja Fischer
• 金额: $ 52.34万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT130101875
• 关键词: MOLECULAR; APPROACHES; OVERCOME; SCABIES; ASSOCIATED

Scabies causes childhood pyoderma predisposing to severe disease in later life. It is a major increasing health burden in Indigenous people of Northern Australia. Drug resistance is developing in mites and bacteria. The lack of clinical material has hampered molecular research and this work will use comparative genomics of parasitic and free living mites and microbiome analysis to understand fundamental aspects of mite biology and pathogenesis. The understanding of proteins that are essential for mite survival and interfere with host defences will allow the informed design of peptide inhibitors as a new strategy to develop alternative treatment options.

疥疮导致儿童期脓毒症，使其在以后的生活中易患严重疾病。这是澳大利亚北方土著人民日益严重的健康负担。螨类和细菌的抗药性正在发展。临床材料的缺乏阻碍了分子研究，这项工作将使用寄生和自由生活螨的比较基因组学和微生物组分析来了解螨生物学和发病机制的基本方面。了解蛋白质是必不可少的螨生存和干扰宿主防御将允许知情的肽抑制剂的设计作为一种新的策略，以开发替代治疗方案。