Presentation of Metabolite Antigens by MR1 Molecules: a Fundamental System of Immune Priming

我们的免疫系统不断监测我们的身体是否有致病微生物，比如导致肺炎或肺结核等疾病的细菌。我们的细胞有一个叫做“MR1”的分子警报系统，它会向白细胞发出微生物感染正在发生的警报，然而这个过程还没有被很好地理解。这笔拨款将使我能够发现控制MR1报警系统的细胞和分子途径，这可能会为我们社区的常见疾病带来新的治疗方法。

Our immune system constantly monitors our body for disease-causing microbes, such as bacteria that cause illnesses like pneumonia or tuberculosis. Our cells have a molecular alarm-system called 'MR1' which alerts white blood cells that an infection by microbes is occurring, however this process is not well understood. This grant will allow me to discover the cells and molecular pathways that govern the MR1 alarm system, which may lead to new treatments against common diseases in our community.