Preventing inflammation-induced brain injury in preterm infants: targeting systemic tumour necrosis factor

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Cerebral palsy is a devastating life-long condition. A large proportion of cases are associated with exposure to inflammation at the time of preterm birth. There is no effective treatment. Our studies will examine how inflammation impairs brain development and function in preterm infants and test whether blocking a key inflammatory protein in the blood, called tumour necrosis factor, improves brain development. We will generate critical knowledge towards reducing disability in preterm infants.