Progesterone regulation of epithelial cell lineages in the breast

卵巢以一种未知的方式在乳腺癌中起着关键作用。黄体酮会增加乳腺癌的风险，激素治疗的反应与肿瘤的孕激素受体含量密切相关，但它是如何做到这一点的尚不清楚。我们将继续我们的发现，即黄体酮影响乳房中的细胞类型，类似于那些癌变的细胞。这将揭示乳腺癌发展中的关键弱点以及预防和治疗的潜在目标。

The ovaries play a pivotal role in breast cancer in ways that are unknown. Progesterone increases breast cancer risk, and response to hormonal treatments is critically associated with tumour progesterone receptor content, but how it does this is unknown. We will pursue our findings that progesterone influences cell types in the breast similar to those that become cancerous. This will uncover critical vulnerabilities in breast cancer development and potential targets for prevention and treatment.