Proguanil: Old Drug, New Tricks

2013年，疟疾临床病例约为2亿例，造成约60万人死亡。所有抗疟药物现在都与疟原虫的抗药性有关。因此，迫切需要新的治疗方法，包括预防这种疾病的新药。我们已经取得了令人兴奋的发现，现有的抗疟疾药物可以杀死疟疾寄生虫在一个独特的，以前未知的方式。在这里，我们将研究这种情况是如何发生的，并开发用于预防疟疾的新候选药物。

In 2013 there were ~200 million clinical cases of malaria, causing ~600,000 deaths. All antimalarial drugs are now associated with malaria parasite resistance. Thus, new therapies are urgently needed, including new drugs to prevent this disease. We have made the exciting discovery that an existing antimalarial drug can kill malaria parasites in a unique, previously unknown, manner. Here, we will investigate how this occurs and develop new drug candidates for malaria prevention.