Amnion cell therapy for acute and chronic stroke

羊膜细胞疗法治疗急性和慢性中风

• 批准号: nhmrc : 2003156
• 金额: $ 108.53万
• 依托单位国家: 澳大利亚
• 项目类别: Ideas Grants
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://researchdata.edu.au/amnion-cell-therapy-chronic-stroke/1780077
• 关键词: Amnion; cell; therapy; acute; chronic

We are studying human amnion epithelial cells (AECs) as a new therapy for stroke. Here if we find the protective effects of AECs are unaffected by a 'clot-buster' drug,we will broaden our planned Phase II trial of AECs to include patients that have received clot lysis therapy. Further, as we suspect that AECs exert their effects via release of nanoparticles called 'exosomes', we will test whether exosomes given intravenously or intranasally are similarly protective.

我们正在研究人羊膜上皮细胞（AECs）作为中风的新疗法。在这里，如果我们发现AEC的保护作用不受“血栓克星”药物的影响，我们将扩大我们计划的AEC II期试验，包括接受血栓溶解治疗的患者。此外，由于我们怀疑AEC通过释放称为“外泌体”的纳米颗粒发挥作用，我们将测试静脉内或鼻内给予的外泌体是否具有类似的保护作用。