Amyloid Precursor Protein Signalosome: directing Abeta production in Alzheimer's disease

淀粉样蛋白前体蛋白信号体：指导阿尔茨海默病中 Abeta 的产生

• 批准号: nhmrc : GNT1103026
• 负责人: Dr Craig Morton
• 金额: $ 68.15万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/amyloid-precursor-protein-alzheimers-disease/1346261
• 关键词: Amyloid; Precursor; Protein; Signalosome; directing

Alzheimer's disease is the most common form of dementia and is the fourth biggest killer in developed countries. Amyloid precursor protein plays a central role in the development of the disease, through the generation of a toxic peptide called Abeta. In this project we will decipher the fine molecular details of what the protein looks like and how various molecules known to bind to it affect Abeta production. This knowledge is expected to lead to novel therapies to treat the disease.

阿尔茨海默病是痴呆症中最常见的一种，是发达国家的第四大杀手。淀粉样前体蛋白通过产生一种称为Abeta的有毒肽，在疾病的发展中起着核心作用。在这个项目中，我们将破译蛋白质的精细分子细节，以及已知与它结合的各种分子如何影响Abeta的产生。这些知识有望导致治疗这种疾病的新疗法。