An epidemiological study to identify new molecular markers of lung cancer risk and survival with a particular focus on never and former smokers.

一项流行病学研究，旨在确定肺癌风险和生存的新分子标记，特别关注从不吸烟者和既往吸烟者。

• 批准号: nhmrc : 1050198
• 负责人: Dr Allison Hodge
• 金额: $ 56.72万
• 依托单位: Cancer Council Victoria
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/an-epidemiological-study-focus-smokers/112142
• 关键词: epidemiological; study; identify; new; molecular

Lung cancer remains the most lethal cancer worldwide, yet little is known of the risk factors beyond that of tobacco smoking and certain occupational exposures. We have assembled a large international consortium comprising 24 cohort studies and over 10,000 to validate associations between B-vitamins and lung cancer risk particularly in never and former smokers. We propose to expand this study and use the Melbourne Collaborative Cohort Study and the rest of the consortium to identify novel biomarkers of risk and survival.

肺癌仍然是世界上最致命的癌症，但除了吸烟和某些职业接触之外，对其风险因素知之甚少。我们组建了一个大型国际联盟，包括24项队列研究和超过10,000项研究，以验证b族维生素与肺癌风险之间的关系，特别是在从不吸烟和曾经吸烟的人群中。我们建议扩大这项研究，并使用墨尔本合作队列研究和其他联盟来确定新的风险和生存的生物标志物。