Real-time visualisation of dendritic cell responses during cutaneous Leishmania infection

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Leishmaniasis is one of the six major tropical diseases identified by the WHO for intense further study. The disease affects millions of people worldwide demanding the development of improved vaccines. A prerequisite is a better understanding of the basic mechanisms of anti-parasite immunity. This proposal will employ a novel approach, intravital two-photon microscopy, to directly visualise Leishmania parasites and immune cells in the skin in order to decipher anti-Leishmania immunity.