Recreating haematopoietic niches to support HSC generation from human pluripotent stem cells and to model bone marrow failure

我们将开发在实验室中利用人类多能干细胞制造血液干细胞的方法，并通过培养类似于细胞在正常发育过程中所遇到的胎儿肝脏和骨髓环境的培养物来扩大造血干细胞。”这些血液干细胞对许多无法找到匹配供体的白血病和骨髓衰竭患者是有益的。此外，这种培养系统将用于了解年轻患者骨髓衰竭的原因。

We will develop a method for making blood stem cells from human pluripotent stem cells in the laboratory and expand them by creating cultures that resemble the fetal liver and bone marrow environments that the cells encounter during normal development. These blood stem cells would be beneficial for many patients with leukaemia and bone marrow failure who cannot find a matched donor. Also, this culture system will be used to understand the causes of bone marrow failure in young patients.