The actions of naltrexone in midbrain reward circuits

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Alcohol use disorders impose significant burden on individual drinkers, their families, and communities. The opioid receptor antagonist naltrexone is one of the few available pharmacotherapies for alcohol use disorders, but its efficacy was incidental to its development, is only modest, and remains poorly understood. This project uses state of the art basic science approaches to identify how naltrexone achieves its therapeutic effects and will identify new ways of improving these.