The actions of naltrexone in midbrain reward circuits

纳曲酮在中脑奖励回路中的作用

• 批准号: nhmrc : GNT1164514
• 金额: $ 86.22万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/actions-naltrexone-midbrain-reward-circuits/1379357
• 关键词: actions; naltrexone; midbrain; reward; circuits

Alcohol use disorders impose significant burden on individual drinkers, their families, and communities. The opioid receptor antagonist naltrexone is one of the few available pharmacotherapies for alcohol use disorders, but its efficacy was incidental to its development, is only modest, and remains poorly understood. This project uses state of the art basic science approaches to identify how naltrexone achieves its therapeutic effects and will identify new ways of improving these.

酒精使用障碍对饮酒者个人、他们的家庭和社区造成重大负担。阿片受体拮抗剂纳曲酮是少数可用于酒精使用障碍的药物治疗之一，但其疗效是偶然的，只是适度的，并且仍然知之甚少。该项目使用最先进的基础科学方法来确定纳曲酮如何达到其治疗效果，并将确定改进这些效果的新方法。