An investigation into metabolic competition between host and pathogen in infection

感染中宿主和病原体之间代谢竞争的研究

• 批准号: nhmrc : GNT1158678
• 金额: $ 64.58万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/an-investigation-metabolic-pathogen-infection/1379042
• 关键词: investigation; into; metabolic; competition; between

Advanced medical treatments come with a high risk of life-threatening microbial infections, and rising antimicrobial drug resistance demands innovative therapeutic strategies. In this project, we will characterize metabolic regulation as a novel therapeutic target in infection, focusing on the human fungal pathogen Candida albicans that causes hospital infections with 40% mortality. Our outcomes will be broadly relevant to designing improved therapies against infectious diseases.

先进的医疗治疗伴随着威胁生命的微生物感染的高风险，而不断增加的抗菌素耐药性需要创新的治疗策略。在这个项目中，我们将把代谢调节描述为感染的一个新的治疗靶点，重点是引起医院感染的人类真菌白色念珠菌，它的死亡率为40%。我们的结果将与设计针对传染病的改进治疗方法广泛相关。