Analysis of the osteoclast methylome for characterisation of epigenetic mechanisms underlying metabolic bone disease

分析破骨细胞甲基化组以表征代谢性骨疾病的表观遗传机制

• 批准号: nhmrc : 2003629
• 金额: $ 29.9万
• 依托单位国家: 澳大利亚
• 项目类别: Ideas Grants
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/analysis-osteoclast-methylome-bone-disease/1780176
• 关键词: Analysis; osteoclast; methylome; characterisation; epigenetic

A large number of genetic variants have been identified that have a role in osteoporosis, however for many of these, the mechanism by which they influence the disease remains to be determined. This study will fill a critical knowledge gap by investigating the epigenetic control of gene expression in osteoclasts (bone resorbing cells). This research will generate a unique international resource that will provide foundation data to understand and treat this prevalent and debilitating bone disease.

已经确定了大量的遗传变异在骨质疏松症中起作用，然而对于其中许多，它们影响疾病的机制仍有待确定。这项研究将填补一个关键的知识空白，调查破骨细胞（骨吸收细胞）的基因表达的表观遗传控制。这项研究将产生一个独特的国际资源，将提供基础数据，以了解和治疗这种流行和衰弱的骨骼疾病。