Ancient proteins and disease.

古老的蛋白质和疾病。

• 批准号: nhmrc : 1008667
• 负责人: A/Pr Todd Mitchell
• 金额: $ 34.42万
• 依托单位: University of Wollongong
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/ancient-proteins-disease/109331
• 关键词: Ancient; proteins; disease.

Most diseases are much more common in the elderly. The reasons are poorly understood. We have evidence that the most common eye diseases, cataract and presbyopia, are due to the fact that the large molecules that make up the lens do not turnover. In lenses of older people proteins, which make up the bulk of the transparent tissue, become degraded. It turns out that very long lived proteins are quite common in the body. This proposal seeks to determine what role degradation of these ancient proteins has in other diseases of aging.

大多数疾病在老年人中更为常见。人们对其中的原因知之甚少。我们有证据表明，最常见的眼病，如白内障和老花眼，都是由于构成晶状体的大分子没有转换。在老年人的晶状体中，构成大部分透明组织的蛋白质被降解了。事实证明，寿命很长的蛋白质在体内很常见。这项提议旨在确定这些古老蛋白质的降解在其他衰老疾病中的作用。