Anthracyclines disrupt Ca2+ signalling in cardiomyocytes: a contribution to cardiac toxicity

蒽环类药物破坏心肌细胞中的 Ca2 信号传导：导致心脏毒性

• 批准号: nhmrc : 1021342
• 负责人: A/Pr Anneke Blackburn
• 金额: $ 35.05万
• 依托单位: University of Canberra
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/anthracyclines-disrupt-ca2-cardiac-toxicity/110113
• 关键词: Anthracyclines; disrupt; Ca2+; signalling; cardiomyocytes

Anthracyclines are one of the most effective drugs used in chemotherapy, but cause side effects resulting in serious heart problems which can be fatal. The link between anthracycline therapy and the problems they cause in the heart is not fully defined. We will investigate mechanisms leading to these side effects and define specific targets of anthracyclines in the heart. It is hoped this will lead to the design of new drugs which counteract the side effects of anthracycline treatment.

蒽环类药物是化疗中最有效的药物之一，但会引起副作用，导致严重的心脏问题，这可能是致命的。蒽环类药物治疗和它们在心脏中引起的问题之间的联系还没有完全确定。我们将研究导致这些副作用的机制，并确定蒽环类药物在心脏中的特定靶点。人们希望这将导致设计新的药物，抵消蒽环类药物治疗的副作用。