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Anthracyclines disrupt Ca2+ signalling in cardiomyocytes: a contribution to cardiac toxicity

Anthracyclines disrupt Ca2+ signalling in cardiomyocytes: a contribution to cardiac toxicity
蒽环类药物破坏心肌细胞中的 Ca2 信号传导:导致心脏毒性
批准号:
nhmrc : 1021342
负责人:
A/Pr Anneke Blackburn
金额:
$35.05万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2012
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2012-01-01 至 2015-12-31

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英文摘要
Anthracyclines are one of the most effective drugs used in chemotherapy, but cause side effects resulting in serious heart problems which can be fatal. The link between anthracycline therapy and the problems they cause in the heart is not fully defined. We will investigate mechanisms leading to these side effects and define specific targets of anthracyclines in the heart. It is hoped this will lead to the design of new drugs which counteract the side effects of anthracycline treatment.
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Prevention of drug toxicities with dichloroacetic acid - The implications for cancer chemotherapy
  • 批准号:
    nhmrc : 1049517
  • 项目类别:
    Project Grants
  • 资助金额:
    $36.0万
  • 财政年份:
    2013
  • 负责人:
    A/Pr Anneke Blackburn
  • 依托单位:
Glutathione transferase deficient mice to probe for adverse drug reactions
  • 批准号:
    nhmrc : 418071
  • 项目类别:
    NHMRC Project Grants
  • 资助金额:
    $37.54万
  • 财政年份:
    2007
  • 负责人:
    A/Pr Anneke Blackburn
  • 依托单位:
Investigation of novel mouse mammary tumour susceptibility loci in mice and humans
  • 批准号:
    nhmrc : 366787
  • 项目类别:
    Career Development Fellowships
  • 资助金额:
    $30.83万
  • 财政年份:
    2006
  • 负责人:
    A/Pr Anneke Blackburn
  • 依托单位:
Title of tyrosine catabolism genes and accumulation of assoc metabolites in mouse mammary epithelium-potential low penet
  • 批准号:
    nhmrc : 179842
  • 项目类别:
    Early Career Fellowships
  • 资助金额:
    $16.97万
  • 财政年份:
    2002
  • 负责人:
    A/Pr Anneke Blackburn
  • 依托单位:
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