Anti-Malarial Agents Targeting Apical Membrane Antigen 1

针对顶膜抗原 1 的抗疟药

• 批准号: nhmrc : 1098884
• 负责人: Dr Sheena Mcgowan
• 金额: $ 45.38万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/anti-malarial-agents-antigen-1/662407
• 关键词: Anti; Malarial; Agents; Targeting; Apical

Malaria is a major global health problem. The protein AMA1 plays a key role in the invasion of host cells by malaria parasites, and agents that inhibit this interaction prevent host cell invasion and thus represent leads for the development of anti-malarial drugs. We have identified a number of chemical scaffolds that target a key site on AMA1. In this project we will optimize these leads to generate potent ligands for this site and evaluate the efficacy of these ligands as anti-malarial agents.

疟疾是一个重大的全球健康问题。蛋白质AMA1在疟疾寄生虫入侵宿主细胞中起关键作用，抑制这种相互作用的药物可防止宿主细胞入侵，因此代表了开发抗疟疾药物的线索。我们已经确定了一些化学支架，目标是AMA1上的关键位点。在这个项目中，我们将优化这些线索，为这个网站产生有效的配体，并评估这些配体作为抗疟疾药物的疗效。