Anti-viral immune dysfunction in severe asthma varies across inflammatory phenotypes.

严重哮喘的抗病毒免疫功能障碍因炎症表型而异。

• 批准号: nhmrc : GNT1128010
• 负责人: A/Pr Christopher Grainge
• 金额: $ 99.72万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/anti-viral-immune-inflammatory-phenotypes/1347659
• 关键词: Anti; viral; immune; dysfunction; severe

Common cold viruses often trigger asthma flare-ups , but have relatively minor effects on healthy people. Why this happens is not clear. We have identified two different ways in which the immune system can react badly to a common cold virus in people with asthma. In this study we will find out more about why the immune system does not react normally in a large group of people with severe asthma. This study will help us discover improved treatments that can be targeted to people with asthma.

普通感冒病毒经常引发哮喘发作，但对健康人的影响相对较小。目前尚不清楚为什么会发生这种情况。我们已经确定了哮喘患者免疫系统对普通感冒病毒做出不良反应的两种不同方式。在这项研究中，我们将更多地了解为什么免疫系统在一大群严重哮喘患者中不能正常反应。这项研究将帮助我们发现可以针对哮喘患者的改进治疗方法。