The anti-thrombotic potential of immunoreceptors in platelet thrombus formation

血小板是血流中的小细胞，通过粘附在一起并形成止血栓，在防止组织损伤部位的过度失血中发挥重要作用。血小板在病变血管中过度聚集会导致阻塞，并引发血栓性疾病，如心脏病发作和中风，这是西方世界人类的两大杀手。在这个提议中，我们将试图了解血小板表面表达的免疫受体如何调节血小板胶原蛋白相互作用的功能，包括胶原蛋白GPVI受体、低亲和力IgG受体、Fc γ RIIa和主要的血小板整合素α IIb β 3。这项工作的目的将确定这些受体在血小板聚集的作用，无论是在基于细胞的测定和小鼠血栓形成模型。这项工作可能会导致血栓性疾病的治疗管理的新策略。

Platelets are small cells in the blood stream that play an important role in preventing excessive blood loss at sites of tissue injury by sticking together and forming a haemostatic plug. Excessive platelet clumping in diseased blood vessels can lead to blockages and cause thrombotic diseases such as heart attack and stroke, two of the biggest killers of humans in the western world. In this proposal, we will seek to understand how immunoreceptors expressed on the surface of platelets modulate the function of platelet collagen interactions involving collagen GPVI receptor, the low affinity IgG receptor, FcgammaRIIa and the major platelet integrin, integrin alphaIIbbeta3. The aims of this work will define the role of these receptors in platelet aggregation both in cell-based assays and in mouse models of thrombosis. This work could lead to new strategies for therapeutic management of thrombotic disorders.