The characterisation of the functional regions of sarcomeric alpha-actinins and to determine how the absence of alpha-actinin-3 influences human skeletal muscle function and metabolism.

肌节 α-肌动蛋白功能区域的表征，并确定 α-肌动蛋白-3 的缺失如何影响人类骨骼肌功能和代谢。

• 批准号: nhmrc : 1038991
• 负责人: Ms Xi Fiona Zheng
• 金额: $ 6.36万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Postgraduate Scholarships
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/characterisation-functional-regions-function-metabolism/111236
• 关键词: characterisation; functional; regions; sarcomeric; alpha

We are studying a muscle protein called a-actinin-3. This protein is absent in approximately one billion people worldwide. A-actinin-3 is associated with athletic performance. Our goal is to explore how the absence of a-actinin-3 influences human skeletal muscle function and metabolism. We will be studying a-actinin-3 deficiency using a mouse model.

我们正在研究一种叫做α-辅肌动蛋白-3的肌肉蛋白。这种蛋白质在全世界约10亿人中缺乏。A-actinin-3与运动成绩有关。我们的目标是探索缺乏α-辅肌动蛋白-3如何影响人类骨骼肌功能和代谢。我们将使用小鼠模型研究α-辅肌动蛋白-3缺乏症。