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The contribution of gp130-Stat3 during Wnt-beta-catenin induced intestinal cancer

The contribution of gp130-Stat3 during Wnt-beta-catenin induced intestinal cancer
gp130-Stat3 在 Wnt-β-catenin 诱导的肠癌中的作用
批准号:
nhmrc : 603127
负责人:
Dr Michael Buchert
金额:
$26.42万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2010
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2010-01-01 至 2012-12-31

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英文摘要
There is growing evidence that cancer is initiated and develops not by the deregulation of a single gene or signaling pathway, but by multiple events. We will study the co-operation between two pathways - gp130-Stat and Wnt. These signaling pathways are frequently deregulated in many types of cancer, however their interaction remains poorly understood. We shall explore their mechanism of interaction during intestinal cancer in order to develop a novel therapeutic target for this disease.
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会议论文
Exploiting the cross talk between Tuft cells and group 2 innate lymphoid cells for tissue homeostasis and disease
  • 批准号:
    nhmrc : 1143020
  • 项目类别:
    Project Grants
  • 资助金额:
    $56.2万
  • 财政年份:
    2018
  • 负责人:
    Dr Michael Buchert
  • 依托单位:
国内基金
海外基金
EGR1/gp130轴调节铁代谢在低氧微环境促宫颈癌细胞免疫逃逸中的作用及机制研究
复方清胰汤对肠道菌群、黏膜屏障功能以及对 IL-6/gp130 信 号通路的影响机制研究
IL11-IL11Rα/GP130通过ERK信号通路促进克罗恩病爬行脂肪纤维化形成的机制研究
  • 批准号:
    --
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    30万元
  • 批准年份:
    2022
  • 负责人:
    熊珊珊
  • 依托单位:
GP130信号阻滞CAR-T细胞耗竭的机制研究