The Effect of Aging on Cardiovascular Disease Prediction

心血管疾病是老年人死亡和残疾的主要原因。我们的目的是研究：(i)传统心血管疾病危险因素预测老年人主要心血管不良事件（MACE）的能力及其与虚弱的相互作用；（ii） CT冠状动脉造影斑块负荷预测老年人主要心血管不良事件（MACE）的能力及其与传统风险评分相比的增量预测价值；（iii）血小板激活途径是否随着年龄的增长而不同

Cardiovascular disease is a leading cause of death and disability in the elderly. We aim to investigate: (i) the ability of traditional CVD risk factors to predict major adverse cardiovascular events (MACE) in the elderly and their interaction with frailty (ii) the ability of plaque burden on CT coronary angiogram to predict MACE in older populations and its incremental predictive value compared to traditional risk scoring (iii) whether platelet activation pathways differ with increasing age