The effect of heterogeneity and airway closure on distensibility measurements in asthma

异质性和气道闭合对哮喘扩张性测量的影响

• 批准号: nhmrc : 521808
• 负责人: Dr Vanessa Kelly
• 金额: $ 2.34万
• 依托单位: Alfred Hospital
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Postgraduate Scholarships
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/effect-heterogeneity-airway-measurements-asthma/115811
• 关键词: effect; heterogeneity; airway; closure; distensibility

Long term asthma can result in stiffening of the airways, which cannot currently be measured with standard lung function tests. A new non-invasive technique, using sound, has been shown to measure airway stiffness, but this may be adversely influenced by other respiratory changes that occur with asthma (airway closure, heterogeneity). We are investigating the effects of these confounding factors to fully characterise this novel technique, so that it can be used in the clinical environment.

长期哮喘可导致气道硬化，目前无法用标准肺功能测试测量。一种新的非侵入性技术，使用声音，已被证明可以测量气道硬度，但这可能会受到哮喘发生的其他呼吸变化（气道关闭，异质性）的不利影响。我们正在研究这些混杂因素的影响，以充分验证这种新技术，使其能够在临床环境中使用。