The effect of heterogeneity and airway closure on distensibility measurements in asthma

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Long term asthma can result in stiffening of the airways, which cannot currently be measured with standard lung function tests. A new non-invasive technique, using sound, has been shown to measure airway stiffness, but this may be adversely influenced by other respiratory changes that occur with asthma (airway closure, heterogeneity). We are investigating the effects of these confounding factors to fully characterise this novel technique, so that it can be used in the clinical environment.