The effect of overexpression and underexpression of beacon in transgenic mice

Beacon过表达和低表达对转基因小鼠的影响

• 批准号: nhmrc : 209002
• 负责人: Dr Jenny Favaloro
• 金额: $ 21.11万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/effect-overexpression-underexpression-transgenic-mice/97875
• 关键词: effect; overexpression; underexpression; beacon; transgenic

Overweight and Obesity are very prevalent in our society. Obesity is the cause of many medical problems including type 2 diabetes, high blood pressure, abnormal lipids, sleep apnoea, arthritis and some cancers. The idea that individuals can freely choose whether they eat or not eat is only true in the short term. Recent work has clearly shown that the desire to eat (hunger) and the decision to stop eating (satiety) are determined by the net level of many chemicals (neurotransmitters) in an area of the brain called the hypothalamus. Malfunction in some of these neurotransmitters has been shown to cause severe obesity in both animals and humans. A clear understanding of how the hypothalamus regulates body weight may lead to treatments for both severe obesity and anorexia. This project deals with investigating the role of a new hypothalamic protein in body weight regulation. This protein called beacon was discovered by one of the chief investigators (GC) who has shown that when it is injected in the brain it causes rats to overeat and put on excess weight. The aim of this project is to produce mice in which the amount of beacon is increased in the brain and other mice who do not have beacon and then to study the impact onthe regulation of body weight.

超重和肥胖在我们的社会中非常普遍。肥胖是许多医学问题的原因，包括2型糖尿病、高血压、血脂异常、睡眠呼吸暂停、关节炎和一些癌症。个人可以自由选择吃或不吃的想法只是在短期内是正确的。最近的研究清楚地表明，吃东西的欲望（饥饿）和停止吃东西的决定（饱腹感）是由大脑中一个叫做下丘脑的区域的许多化学物质（神经递质）的净水平决定的。这些神经递质中的一些功能失调已被证明会导致动物和人类的严重肥胖。清楚地了解下丘脑如何调节体重可能会导致严重肥胖和厌食症的治疗。该项目旨在研究一种新的下丘脑蛋白在体重调节中的作用。这种名为“灯塔”的蛋白质是由一位首席研究员（GC）发现的，他已经证明，当将这种蛋白质注射到大脑中时，它会导致老鼠暴饮暴食，体重增加。本项目的目的是制造出大脑中beacon数量增加的小鼠和其他没有beacon的小鼠，然后研究其对体重调节的影响。