The effect of titanium surface modification on the immuno-regulation of osseointegration.

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Titanium implants are an established treatment modality in both dentistry and orthopaedics. This project will determine how implant surface modification can modulate the inflammatory response and subsequent differentiation of stem cells involved in the process of integrating the implant with bone i.e. osseointegration. The identification of the molecular mechanisms involved will thus provide leads for novel ways to further to enhance the osseointegration process and improve clinical outcomes.