The Effects of Human Epilepsy Mutations on Synaptic GABA-A Receptors Studied by Localization-based Superresolution Microscopy

遗传性癫痫是一种使人衰弱的神经系统疾病，通常与大脑中编码神经递质门控受体的基因突变有关。该项目的目标是了解在单一受体水平上引起神经元通信变化并导致癫痫的机制。这将导致对癫痫发生机制的更好理解和对治疗不同癫痫方法的新见解。

The genetic epilepsies are debilitating neurological disorders that are frequently associated with mutations in genes encoding neurotransmitter-gated receptors in the brain. The goal of this project is to understand mechanisms that cause changes in neuronal communication and lead to epilepsy on a single receptor level. This will lead to an improved understanding of the mechanisms of epileptogenesis and new insights into ways of treating different epilepsies.