The enemy within: epithelial defence against cell death.

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Epithelial tissues (e.g. gut, skin) are necessary barriers that protect the body from potential environmental toxins and infection. But epithelial barriers can be compromised when their constituent cells die, either during normal tissue turnover or upon noxious stress. This project investigates a novel protective mechanism, based on how cells detect changes in mechanical tension, that eliminates dead cells to preserve epithelial barriers during health and protects against inflammation.