The genetics and mechanisms of resistance to the zoonotic highly pathogenic influenza virus in avian species

禽类对人畜共患高致病性流感病毒的遗传学和抵抗机制

• 批准号: nhmrc : 1091865
• 金额: $ 22.5万
• 依托单位: CSIRO
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/genetics-mechanisms-resistance-avian-species/650759
• 关键词: genetics; mechanisms; resistance; zoonotic; highly

Highly pathogenic avian influenza (HPAI) poses a serious pandemic risk. This project will investigate the genetic basis and mechanisms underlying resistance to HPAI in birds. It will explore the role of immune genes in resistance to HPAI in six bird species which vary in their susceptibility to HPAI. Functional tests of resistance genes will be performed to determine how these genes can provide resistance to HPAI. This study will assist in the development of strategies to mitigate disease risks.

高致病性禽流感（HPAI）构成严重的大流行风险。本项目将研究鸟类抗高致病性禽流感的遗传基础和机制。它将探讨免疫基因在六种鸟类中对高致病性禽流感的抗性中的作用，这些鸟类对高致病性禽流感的易感性各不相同。将进行抗性基因的功能测试，以确定这些基因如何提供对HPAI的抗性。这项研究将有助于制定减轻疾病风险的战略。