The Importance of Classical Versus Backdoor Androgen Production Pathways in Masculinisation, Fertility and Lifelong Male Health

男性的发育、生育和终身健康从根本上是由睾丸雄激素支持的。几十年来，我们一直认为我们完全了解雄激素是如何产生的，然而最近的研究发现了第二种“后门”途径，在男性发育中起着关键作用。我们将有选择地阻断小鼠的其中一种（或两种）途径，以确定每一种途径如何促进正确的雄性发育和功能。获得的独特知识将支持支持男性终身健康的努力。

Male development, fertility, and lifelong health are fundamentally supported by testicular androgens. For decades we believed we fully understood how androgens are produced, however recent research has identified a second 'backdoor' pathway playing a key role in male development. We will selectively block either (or both) pathways in mice to determine how each promotes correct male development and function. The unique knowledge gained will underpin efforts to support lifelong male health.