The Iron Clock: Epigenetic regulation of circadian iron homeostasis

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Levels of iron in the blood fluctuate over the day, but the reasons for this have never been defined. Just as insulin is critical to glucose homeostasis, hepcidin fundamentally regulates iron metabolism. This project will define the mechanisms by which the master regulator of iron levels, hepcidin, varies across a 24 hour cycle. It will use a series of cutting edge techniques to pinpoint the key regulators of this system and provide both scientific and clinically translatable knowledge.