The Iron Clock: Epigenetic regulation of circadian iron homeostasis

血液中的铁含量在一天中波动，但其原因从未被确定。就像胰岛素对葡萄糖稳态至关重要一样，hepcidin从根本上调节铁代谢。该项目将确定铁水平的主要调节器hepcidin在24小时周期内变化的机制。它将使用一系列尖端技术来确定该系统的关键调节因子，并提供科学和临床可翻译的知识。

Levels of iron in the blood fluctuate over the day, but the reasons for this have never been defined. Just as insulin is critical to glucose homeostasis, hepcidin fundamentally regulates iron metabolism. This project will define the mechanisms by which the master regulator of iron levels, hepcidin, varies across a 24 hour cycle. It will use a series of cutting edge techniques to pinpoint the key regulators of this system and provide both scientific and clinically translatable knowledge.