The link between dopamine and brain circuit dysfunction in early psychosis

多巴胺与早期精神病中脑回路功能障碍之间的联系

• 批准号: nhmrc : GNT1066779
• 负责人: A/Pr Benjamin Harrison
• 金额: $ 82.86万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/link-dopamine-brain-early-psychosis/1344918
• 关键词: link; between; dopamine; brain; circuit

Psychosis is a debilitating psychiatric syndrome affecting a person’s ability to understand reality. This project will map how disruptions of specific brain circuits give rise to psychosis, and how they relate to changes in the level of a specific brain chemical, dopamine, which is targeted by antipsychotic medications. This work has important implications for developing new, more targeted treatments.

精神病是一种使人衰弱的精神综合症，影响一个人理解现实的能力。该项目将绘制特定大脑回路的破坏如何引起精神病，以及它们与抗精神病药物针对的特定大脑化学物质多巴胺水平变化的关系。这项工作对于开发新的、更有针对性的治疗方法具有重要意义。