Antiphospholipid Syndrome Related Thrombosis: Understanding the disease pathogenic mechanisms is the key to better diagnosis and treatment

抗磷脂综合征相关血栓形成：了解疾病致病机制是更好诊断和治疗的关键

• 批准号: nhmrc : 1025143
• 负责人: Dr Bill Giannakopoulos
• 金额: $ 40.51万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/antiphospholipid-syndrome-related-diagnosis-treatment/110410
• 关键词: Antiphospholipid; Syndrome; Related; Thrombosis; Understanding

Patients with the Antiphospholipid Syndrome develop thrombosis at a young age. It requires long-term treatment with blood thinning medications, which have risks of severe bleeding. Methods are needed to decide which patients require long term treatment, avoiding unnecessary treatment in low risk patients. Such methods do not currently exist. In this study we explore how useful two novel assays developed by us are in identifying which of these patients are at high risk of thrombosis.

抗磷脂综合征患者在年轻时就会出现血栓形成。它需要长期使用血液稀释药物治疗，这有严重出血的风险。需要确定哪些患者需要长期治疗，避免对低风险患者进行不必要的治疗。这种方法目前还不存在。在这项研究中，我们探讨了我们开发的两种新的检测方法在确定这些患者中哪些是血栓形成的高风险患者中的有用性。