Aromatase regulation by p53 and HIF-1alpha in obesity and post-menopausal breast cancer.

p53 和 HIF-1α 在肥胖和绝经后乳腺癌中对芳香酶的调节。

• 批准号: nhmrc : 1005735
• 负责人: Dr Olivier Latchoumanin
• 金额: $ 40.51万
• 依托单位: Prince Henry's Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/aromatase-regulation-p53-breast-cancer/109109
• 关键词: Aromatase; regulation; p53; HIF; 1alpha

Current hormone therapy for breast cancer using inhibitors of oestrogen production results in serious side-effects including bone loss, joint pain and possibly cognitive issues. Our current work is aimed at understanding how oestrogen production is regulated with the goal of developing breast-specific inhibitors of oestrogen production to obviate these problems. In addition, this work is aimed at devising therapeutic intervention to break the linkage between obesity and breast cancer.

目前使用雌激素抑制剂治疗乳腺癌的激素疗法会导致严重的副作用，包括骨质流失、关节疼痛和可能的认知问题。我们目前的工作旨在了解雌激素的产生是如何被调节的，目的是开发乳房特异性的雌激素产生抑制剂来消除这些问题。此外，这项工作旨在设计治疗干预来打破肥胖和乳腺癌之间的联系。