Assessing the role of the N-terminus of the prion protein, emphasising constitutive cleavage, in normal function and pathogenesis, as well as defining the relationship between intensity of surveillance and sporadic CJD incidence.

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As a neurologist undertaking research into prion diseases over an extended period, I have been able to lead and participate in many projects that have made significant contributions, such as validation of new diagnostic tests for Creutzfeldt-Jakob disease (CJD), assessment of potential therapeutics, provide insights into the normal function of the prion protein and the underlying pathways causing cellular damage and determine the real significance of apparent clusters of sporadic CJD.