Assessing the role of the N-terminus of the prion protein, emphasising constitutive cleavage, in normal function and pathogenesis, as well as defining the relationship between intensity of surveillance and sporadic CJD incidence.

评估朊病毒蛋白 N 末端在正常功能和发病机制中的作用，强调组成型切割，并确定监测强度与散发性克雅氏病发病率之间的关系。

• 批准号: nhmrc : 1005816
• 负责人: Prof Steven Collins
• 金额: $ 25.84万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Practitioner Fellowship
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/assessing-role-n-cjd-incidence/109115
• 关键词: Assessing; role; terminus; prion; protein

As a neurologist undertaking research into prion diseases over an extended period, I have been able to lead and participate in many projects that have made significant contributions, such as validation of new diagnostic tests for Creutzfeldt-Jakob disease (CJD), assessment of potential therapeutics, provide insights into the normal function of the prion protein and the underlying pathways causing cellular damage and determine the real significance of apparent clusters of sporadic CJD.

作为一名长期从事朊病毒疾病研究的神经学家，我能够领导和参与许多做出重大贡献的项目，如克雅氏病（CJD）新诊断测试的验证，潜在治疗方法的评估，提供有关朊病毒蛋白正常功能和导致细胞损伤的潜在途径的见解，并确定的真实的意义散发性克雅氏病的明显集群