The physiological and pathophysiological relevance of glucagon-like-peptide-1 receptor biased agonism

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The glucagon-like peptide-1 receptor is a major drug target for treatment of type 2 diabetes and obesity. Different drugs acting at this receptor are capable of producing distinct physiological outputs, but a detailed understanding of the profile of receptor response that provides optimal clinical effectiveness is lacking. This project addresses this critical knowledge gap and will lead to improved for strategies to screen and develop new and better medicines.