Two recently identified calcium transporters in lactation and during mammary epithelial cell apoptosis.

钙向牛奶中的运输是人类健康的关键事件。除了在新生儿营养方面的重要性外，乳腺细胞调节钙的方式也与乳腺癌有关，也与免疫中重要蛋白质的修饰以及生物制药的活性有关。这笔赠款将确定两种特定的钙转运体如何调节乳房中的钙水平，以及它们在细胞过程中的各自作用，这些过程对正常功能和疾病都很重要。

The transport of calcium into milk is a key event in human health. In addition to its importance in neonatal nutrition, the way breast cells regulate calcium also has implications in breast cancer, as well as the modification of proteins important in immunity, and the activity of biopharmaceuticals. This grant will determine how two specific calcium transporters regulate calcium levels in the breast and their respective roles in cellular processes important in normal function and in disease.