Assessment of the mechanisms involved and severity of arterial disease in insulin resistant states

2型糖尿病是动脉粥样硬化或血管狭窄的主要危险因素。这可能导致血管并发症，如心脏病发作、中风和截肢。本研究旨在探讨一些机制之间的关系，以及它们在从正常健康发展到胰岛素抵抗到糖尿病的血管疾病中的作用。这一认识将为糖尿病血管疾病提供诊断工具和治疗靶点。

Type 2 Diabetes is a major risk factor towards atherosclerosis or blood vessel narrowing. This can lead to vascular complications such as heart attacks, strokes and amputations. This research aim to examine the relationship between some of the mechanisms and their contribution towards vascular disease in the progression from normal health, through insulin resistance to diabetes. This understanding will provide diagnostic tools and treatment targets for diabetic vascular disease.