Assessment of oxidant stress and mitochondrial dysfunction in young adults with iron loading diseases

患有铁负荷疾病的年轻人氧化应激和线粒体功能障碍的评估

• 批准号: nhmrc : 613689
• 负责人: Dr Patrick Walter
• 金额: $ 40.14万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/assessment-oxidant-stress-loading-diseases/100868
• 关键词: Assessment; oxidant; stress; mitochondrial; dysfunction

Disorders of iron metabolism are particularly prevalent in Australia and the consequences of excess iron can be severe. Liver disease is frequently associated with iron loading. The commonest form of iron loading can be treated readily, but it is unclear when the first signs of tissue damage occur and thus at what stage treatment should commence. This project will examine in detail the relationship between body iron levels and signs of tissue damage in young subjects with iron loading disease.

铁代谢紊乱在澳大利亚特别普遍，过量铁的后果可能很严重。肝脏疾病通常与铁负荷有关。最常见的铁负荷形式可以很容易地治疗，但尚不清楚何时出现组织损伤的第一个迹象，因此应在哪个阶段开始治疗。该项目将详细研究体内铁水平与铁负荷疾病年轻受试者组织损伤迹象之间的关系。