B cell activation generates antibodies to promote vascular and renal inflammation, remodelling and dysfunction in hypertension

B 细胞激活产生抗体，促进高血压患者的血管和肾脏炎症、重塑和功能障碍

• 批准号: nhmrc : GNT1146314
• 负责人: Ms Maria Jelinic
• 金额: $ 31.88万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/b-cell-activation-dysfunction-hypertension/1348751
• 关键词: cell; activation; generates; antibodies; promote

Hypertension is a major contributor to chronic cardiovascular and renal diseases, with recent literature suggesting the pathogenesis is similar to that of autoimmune diseases. This fellowship will enhance the current understanding of the pathogenesis of hypertension and the associated inflammation of the kidneys and vasculature. It will also assess the therapeutic potential of drugs that dampen the immune response in several animal models of hypertension.

高血压是慢性心血管和肾脏疾病的主要诱因，最近的文献表明其发病机制与自身免疫性疾病相似。该奖学金将加强目前对高血压发病机制和相关的肾脏和血管炎症的理解。它还将评估在几种高血压动物模型中抑制免疫反应的药物的治疗潜力。