Bifunctionalised Contrast Nanoparticles for Simultaneous Diagnosis and Treatment of Thrombosis, Vulnerable Plaques and Inflammation

用于同时诊断和治疗血栓形成、易损斑块和炎症的双功能对比纳米颗粒

• 批准号: nhmrc : 1037310
• 负责人: Dr Hang Ta
• 金额: $ 27.53万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/bifunctionalised-contrast-nanoparticles-plaques-inflammation/111068
• 关键词: Bifunctionalised; Contrast; Nanoparticles; Simultaneous; Diagnosis

The aim of this project is to develop bifunctionalised contrast nanoparticles which selectively target molecular markers of cardiovascular and inflammatory diseases at various states. The nanoparticles would provide an advanced imaging technique for early diagnosis of fatty tissue build up in the vessel wall and for detecting vessel blockages. The nanoparticles would also work as drug carrier that specifically brings curative drugs to the disease site for an acute treatment simultaneously with diagnosis.

该项目的目的是开发双功能造影剂纳米颗粒，选择性靶向各种状态下的心血管和炎症疾病的分子标志物。纳米粒子将提供一种先进的成像技术，用于早期诊断血管壁中的脂肪组织积聚和检测血管阻塞。纳米颗粒还可以作为药物载体，专门将治疗药物带到疾病部位，进行急性治疗和诊断。