Analytical bacterial metabolite detection system

分析型细菌代谢物检测系统

• 批准号: 345400-2007
• 负责人: Schellhorn, Herbert
• 金额: $ 7.09万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments - Category 1 (<$150,000)
• 财政年份: 2006
• 资助国家: 加拿大
• 起止时间: 2006-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=326083
• 关键词: Analytical; bacterial; metabolite; detection; system

This proposal is for analytical equipment that will allow us to quantify minute changes in a large number of different metabolites in biological samples.  This will have broad applicalability in projects that examine the properties of natural and mutant strains of bacteria, the effect of altered gene expression in animal and bacterial samples or the concentration of key metabolites in response to experimental manipulation.  These data will help us to understand how experimental changes affect cellular physiology and metabolism. The proposed equipment will be particularly useful for the study of pathogenic strains of E. coli as these the unique metabolic characteristics of the strains have not yet been examined in detail.

这项提议是关于分析设备的，它将使我们能够量化生物样本中大量不同代谢物的微小变化。这将在检查自然和突变细菌菌株的性质、动物和细菌样本中基因表达改变的影响或响应实验操作的关键代谢物浓度的项目中具有广泛的适用性。这些数据将帮助我们了解实验变化如何影响细胞生理和新陈代谢。拟议的设备将对致病菌株的研究特别有用，因为这些菌株的独特代谢特征尚未得到详细检查。