Bioenergetic deficit in neurodegeneration: studies in motor neuron disease (MND)

神经退行性疾病中的生物能缺陷：运动神经元疾病 (MND) 的研究

• 批准号: nhmrc : GNT1101085
• 负责人: Dr Frederik Steyn
• 金额: $ 30.1万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/bioenergetic-deficit-neurodegeneration-disease-mnd/1346146
• 关键词: Bioenergetic; deficit; neurodegeneration; studies; motor

Motor neurone disease (MND) is a fatal neurodegenerative disease. There is no known cause and no known cure. We believe that a defect in the way in which the muscle and nerve cells generate energy to sustain survival causes for there to be added metabolic stress on their already high energetic load, ultimately leading to cell death. This project aims to understand the vicious cycle of energy deficiency that leads to the catastrophic events that cause the death of muscle and nerve cells.

运动神经元疾病（MND）是一种致命的神经退行性疾病。没有已知的原因，也没有已知的治疗方法。我们认为，肌肉和神经细胞产生能量以维持生存的方式存在缺陷，会导致其本来就很高的能量负荷增加代谢压力，最终导致细胞死亡。该项目旨在了解能量缺乏的恶性循环，这种循环会导致灾难性事件，从而导致肌肉和神经细胞死亡。