Biomarkers in Barrett's Oesophagus and Oesophageal Adenocarcinoma

巴雷特食管和食管腺癌的生物标志物

• 批准号: nhmrc : 1094423
• 负责人: Dr Oliver Fisher
• 金额: $ 4.51万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Postgraduate Scholarships
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/biomarkers-barretts-oesophagus-oesophageal-adenocarcinoma/650767
• 关键词: Biomarkers; Barrett; Oesophagus; Oesophageal; Adenocarcinoma

Barrett’s oesophagus (BO) is a condition in which the normal lining of the lower oesophagus is replaced with intestine-like tissue as a response to long-standing acid reflux. BO can progress to oesophageal adenocarcinoma (OAC), an aggressive cancer with poor 5-year survival rates of ~15%. This project aims at detecting genetic and molecular changes that occur in both BO and OAC and which may help predict the risk of progression as well as survival for patients affected by this disease entity.

巴雷特食道(BO)是一种食道下段的正常衬里被肠样组织取代的情况，这是对长期存在的酸反流的反应。BO可进展为食管腺癌(OAC)，这是一种侵袭性癌症，5年生存率很低，约为15%。该项目旨在检测BO和OAC中发生的遗传和分子变化，这可能有助于预测受该疾病实体影响的患者的进展风险和生存。