Bisphosphonate use, oral flora, saliva, gingival crevicular fluid and bone markers in patients with jaw osteonecrosis

颌骨坏死患者双膦酸盐的使用、口腔菌群、唾液、龈沟液和骨标志物

• 批准号: nhmrc : 520172
• 负责人: Dr Claudine Tsao
• 金额: $ 8.12万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Postgraduate Scholarships
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/bisphosphonate-use-oral-jaw-osteonecrosis/115773
• 关键词: Bisphosphonate; use; oral; flora; saliva

Bisphosphonates are used in patients with bones that break easily due to conditions such as osteoporosis. Recent research suggests a possible association between these drugs and jaw bone breakdown called jaw osteonecrosis - a devastating condition with no current effective treatment. It is unclear why this condition affects only jaw bones. This study seeks to investigate if bacteria in the mouth, gum disease and saliva are involved in jaw osteonecrosis, which can then help to improve management.

双膦酸盐用于骨质疏松症等骨质容易断裂的患者。最近的研究表明，这些药物和颌骨断裂之间可能存在联系，称为颌骨坏死-一种目前没有有效治疗的破坏性疾病。目前还不清楚为什么这种情况只影响颌骨。这项研究旨在调查口腔中的细菌、牙龈疾病和唾液是否与颌骨骨坏死有关，这有助于改善治疗。