Bitopic ligands as a novel approach to G-protein-coupled receptor selectivity

双位配体作为 G 蛋白偶联受体选择性的新方法

• 批准号: nhmrc : 1011920
• 负责人: Dr Jonathan Lane
• 金额: $ 36.03万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/bitopic-ligands-novel-receptor-selectivity/109620
• 关键词: Bitopic; ligands; novel; approach; protein

This project will focus on two important types of brain proteins that have been implicated in various symptoms associated with schizophrenia. The aim is to exploit a new paradigm of drug action that we have discovered, whereby novel compounds can be utilized to simultaneously target multiples sites on these brain proteins, in an effort to discover new mechanisms that can promote more selective signalling and, ultimately, can be used to design safer and more effective medicines.

该项目将重点关注与精神分裂症相关的各种症状有关的两种重要类型的脑蛋白。其目的是利用我们发现的药物作用的新范式，从而可以利用新型化合物同时靶向这些大脑蛋白质上的多个位点，努力发现可以促进更多选择性信号传导的新机制，并最终可用于设计更安全，更有效的药物。