Building mitochondrial Complex I, the first assembly of the cells powerplant.

构建线粒体复合物 I，这是细胞动力装置的第一个组装。

• 批准号: nhmrc : GNT0602530
• 负责人: Dr Matthew McKenzie
• 金额: $ 59.8万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/building-mitochondrial-complex-cells-powerplant/1344232
• 关键词: Building; mitochondrial; Complex; first; assembly

Complex I is the first complex of the mitochondrial respiratory chain that is involved in producing most of the cell's energy. Mitochondria diseases occur ~1-5,000 live births with defects in Complex I being the most prevalent, often leading to death. Complex I defects have also been implicated in common disease including Parkinson s disease. This study will provide important new information into how Complex I is built and what goes wrong to cause disease.

复合体I是线粒体呼吸链的第一个复合体，参与产生细胞的大部分能量。线粒体疾病发生约1- 5，000例活产，其中复合体I中的缺陷是最普遍的，通常导致死亡。复合物I缺陷也与包括帕金森病在内的常见疾病有关。这项研究将提供重要的新信息，以了解复杂I是如何构建的，以及什么会导致疾病。