CAPLA Study: Catheter ablation for persistent atrial fibrillation. A Multicentre randomised study of pulmonary vein antral isolation (PVAI) alone vs PVAI with posterior Left Atrial wall isolation (PWI)

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Atrial fibrillation (AF) is a common heart rhythm abnormality that affects quality of life with added health care costs. A minimally invasive procedure called catheter ablation (CA) is effective in controlling simple AF (paroxysmal AF) but the best ablation strategy to control a more resistant form of AF (Persistent AF) is unknown. This trial has been designed to address this key gap in knowledge by assessing if adding specific additional ablation to CA will improve outcomes.